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Research progress on the lectin pathway of complement in IgA nephropathy
Xiaoqing Yu1, Hui Gao2, Xifeng Sun3
1The Second Clinical Medical College of Binzhou Medical University, Yantai, China.
Frontiers in Immunology
|March 16, 2026
Summary
Immunoglobulin A (IgA) nephropathy involves IgA deposition and complement lectin pathway activation. Understanding this pathway offers new biomarkers and targeted therapies for IgA nephropathy.
Area of Science:
- Nephrology
- Immunology
- Complement System
Background:
- IgA nephropathy (IgAN) is an autoimmune kidney disease.
- Pathology involves immunoglobulin A (IgA) deposition in the glomerulus.
- The lectin pathway of the complement system is implicated in IgAN development.
Purpose of the Study:
- Review research on the lectin pathway in IgA nephropathy.
- Highlight the role of complement activation in IgAN pathogenesis.
- Explore potential diagnostic and therapeutic strategies targeting the lectin pathway.
Main Methods:
- Literature review of studies on IgA nephropathy and the complement system.
- Analysis of research on lectin pathway components and their association with IgAN.
- Synthesis of findings on biomarkers and therapeutic targets.
Main Results:
- Lectin pathway activation contributes to IgAN by triggering complement cascade.
- Immune complexes and inflammation damage glomerular mesangial cells.
- Urinary complement components may serve as non-invasive biomarkers.
Conclusions:
- Understanding the lectin pathway is crucial for IgAN research.
- Targeting the lectin pathway offers potential for novel IgAN therapies.
- Personalized treatment strategies for IgA nephropathy may emerge.
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