Breast-implant associated unicentric castleman disease: a case report

Area of Science:

• Oncology
• Pathology
• Medical Devices

Background:

• Prosthetic breast implants can lead to rare complications, including ALK-negative anaplastic large cell lymphoma.
• Other uncommon conditions associated with breast implants require consideration in differential diagnoses.

Purpose of the Study:

• To report the first documented case of unicentric Castleman disease (UCD) associated with prosthetic breast implantation.
• To highlight UCD as a potential diagnosis for breast masses in patients with implants.

Main Methods:

• Case report of a 36-year-old female with a history of bilateral breast implants.
• Clinical presentation including fatigue, edema, fevers, and a breast mass.
• Diagnostic workup involving ultrasound and surgical excision with pathological examination.

Main Results:

• Pathological analysis of the excised breast mass revealed features consistent with hyaline-vascular unicentric Castleman disease (UCD).
• This represents the initial reported instance of breast-implant-associated UCD.

Conclusions:

• Unicentric Castleman disease (UCD) is a newly identified rare complication of prosthetic breast implantation.
• The differential diagnosis for breast masses in patients with implants should include UCD.