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An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
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Mechanistic Insights and Therapeutic Advances in Natural Bioactive Compounds as Multi-target Agents in Rheumatoid
K Sunand1, Arpan Kumar Tripathi2, Akhilesh Patel3
1Department of Pharmacology, School of Pharmacy, Anurag University, Venkatapur, Ghatkesar, Hyderabad, Telangana, 500088, India.
Current Rheumatology Reviews
|March 16, 2026
Summary
Natural compounds show promise for rheumatoid arthritis by reducing inflammation and improving immune balance. While effective, challenges like bioavailability and standardization require further research for clinical use.
Area of Science:
- Rheumatology
- Immunology
- Pharmacology
Background:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease causing joint destruction.
- Current treatments face limitations like incomplete response, side effects, and cost.
- Natural bioactive compounds are being explored as multi-target therapeutic agents for RA.
Purpose of the Study:
- To review the mechanisms, potential, limitations, and formulation of natural compounds for RA.
- To evaluate natural compounds as complementary therapies for rheumatoid arthritis.
Main Methods:
- Comprehensive review of preclinical and clinical studies.
- Analysis of natural compounds' effects on RA pathways and immune balance.
- Evaluation of formulation strategies, including nanotechnology.
Main Results:
- Plant, marine, and microbial compounds (polyphenols, flavonoids, etc.) show anti-inflammatory, antioxidant, and immunomodulatory effects.
- These compounds modulate key RA pathways (NF-κB, JAK/STAT) and Th17/Treg balance.
- Clinical trials with curcumin, resveratrol, and boswellic acids improved RA disease activity, but bioavailability is a limitation.
Conclusions:
- Nanotechnology enhances natural compound stability and absorption.
- Natural compounds offer a safer, multi-target approach to complement RA therapies.
- Further large-scale clinical trials are needed to validate efficacy and reproducibility.
Keywords:
Rheumatoid arthritisimmune modulationinflammationmulti-target therapynanodelivery systems.natural bioactive compoundsMore Related Videos
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