Related Experiment Video

Updated: Mar 18, 2026

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound
13:48

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound

Published on: April 21, 2023

2.1K

Intravascular Lithotripsy Is Associated With Superior Clinical Outcomes Compared to Atherectomy: A Large-Scale,

Charles D Miks1, Grant K Ozaki1, Chirayu R Shukla1

  • 1Department of Internal Medicine, University of Iowa Health Care, Iowa, USA.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|March 16, 2026
PubMed

Insights

Intravascular lithotripsy (IVL) shows better 1-year outcomes and fewer complications than atherectomy (ATH) for severe coronary calcification. This real-world data supports IVL as a safe alternative for complex coronary lesions.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Medical Device Technology

Background:

  • Severe coronary calcification poses challenges for percutaneous coronary intervention (PCI).
  • Atherectomy (ATH) and intravascular lithotripsy (IVL) are plaque modification techniques.
  • Limited large-scale data compares long-term outcomes of IVL versus ATH.

Purpose of the Study:

  • To compare 1-year clinical outcomes between IVL and ATH.
  • To evaluate 30-day procedural complications associated with IVL and ATH.
  • To analyze temporal trends in the utilization of IVL and ATH.

Main Methods:

  • Retrospective cohort study using TriNetX Research Network data from 47 health organizations.
  • Analysis of adults with coronary artery disease (CAD) undergoing single-vessel PCI with drug-eluting stents (DES) and either IVL or ATH.
  • Propensity matching and evaluation of annual utilization trends from 2013 to 2024.

Main Results:

  • IVL was associated with lower 1-year risks of all-cause mortality, myocardial infarction, and MACE compared to ATH.
  • IVL demonstrated reduced 30-day procedural complications, including less bleeding and contrast-induced acute kidney injury (CA-AKI).
  • IVL utilization rapidly increased, surpassing ATH after 2022.

Conclusions:

  • IVL is linked to more favorable 1-year outcomes and fewer short-term complications than ATH in a real-world setting.
  • Findings support IVL as a safe and effective option for complex coronary lesions.
  • Randomized trials are needed to confirm causality and further validate IVL's efficacy.
Abstract

Keywords:
coronary calcificationdrug‐eluting stentpercutaneous coronary interventionplaque modification

More Related Videos

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug07:50

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

3.2K
Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

2.7K

Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
503
Urinary Tract Calculi VI: Surgical Management01:25

Urinary Tract Calculi VI: Surgical Management

Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
771
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
454
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
280
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
567
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
624