Related Experiment Video
Updated: Mar 18, 2026

Microwave-assisted Intramolecular Dehydrogenative Diels-Alder Reactions for the Synthesis of Functionalized Naphthalenes/Solvatochromic Dyes
Published on: April 1, 2013
Electrochemical cross-dehydrogenative coupling of isochroman with sulfonamide and indole
Liangliang Wu1, Honghong Qin1, Guoping Li1
1College of Chemistry, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052, China. gongming@zzu.edu.cn.
Abstract:
The efficient combination of two medium-sized backbone molecules facilitates the acquisition of hybrid molecular drug candidates. In this paper, we have successfully established a novel electrochemical cross-dehydrogenative coupling reaction of isochroman with sulfonamide and indole to construct hybrid molecules under mild and green reaction conditions. This protocol is carried out at room temperature and does not require any transition metal catalyst or exogenous oxidant. The results of control experiments and cyclic voltammetry experiments showed that the reaction might involve a free radical process.
More Related Videos
07:30A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
Published on: January 21, 2020
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
Published on: June 20, 2014
Related Concept Videos
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Preparation and Reactions of Sulfides
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
Crossed Aldol Reactions: Overview