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Entrectinib-Induced Sinus Bradycardia in a Patient With Metastatic Non-Small Cell Lung Cancer

Azita H Talasaz1, Anne J Goldberg2, Catherine A Shu3

  • 1Department of Pharmacy, New York Presbyterian Hospital/Columbia University Medical Center, New York, New York, USA.

JACC. Case Reports
|March 16, 2026
PubMed
Abstract

Insights

Entrectinib, a targeted therapy for non-small cell lung cancer, can cause rare but serious sinus bradycardia. Patients on ALK/ROS1 inhibitors require cardiac monitoring and multidisciplinary care.

Area of Science:

  • Oncology
  • Pharmacology
  • Cardiology

Background:

  • Tyrosine kinase inhibitors have improved non-small cell lung cancer (NSCLC) outcomes.
  • Entrectinib is effective for ROS1-positive NSCLC, including brain metastases.
  • Rare cardiac adverse events are associated with entrectinib.
Keywords:
cardio-oncologyentrectiniblung cancer

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