Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

1.3K
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
1.3K
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

1.4K
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
1.4K
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

1.4K
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
1.4K
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

1.4K
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
1.4K
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

119
Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
119
Analgesia and Pain Management01:25

Analgesia and Pain Management

2.7K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of medicaid waivers on medication for opioid use disorders in residential facilities: Evidence from twenty-five states.

Drug and alcohol dependence·2026
Same author

Multisite Mobile Addiction Services: Four-Year Outcomes.

International journal of environmental research and public health·2026
Same author

Study Design, Methods, and Modeling in Networks to Inform HIV Interventions and Policy in Marginalized Populations.

Rhode Island medical journal (2013)·2026
Same author

Compiling Comprehensive Databases for Opioid Overdose Monitoring in a Fragmented Health Care System.

Health services research·2026
Same author

Drug Checking Services in Latin America vs. the United States: Staff Perspectives, Program Characteristics, and Barriers to Implementation.

medRxiv : the preprint server for health sciences·2026
Same author

Medicaid Managed Care Plan Alignment With State Substance Use Disorder Treatment Coverage Requirements.

The Milbank quarterly·2026
Same journal

Personalizing N-of-1 Trial Results to Facilitate Decision-Making.

JAMA network open·2026
Same journal

Prostate Cancer Screening-Where We've Been, Where We Are, and What Comes Next.

JAMA network open·2026
Same journal

Comparison of Care Cascade Outcome Measures for Hepatitis C Among Insured US Adults.

JAMA network open·2026
Same journal

At-Home Transvaginal Pelvic Ultrasonography and Image Quality in Premenopausal Women: A Nonrandomized Clinical Trial.

JAMA network open·2026
Same journal

Aerobic Exercise and Subthreshold Depressive Symptoms in Adolescents: Secondary Analysis of a Randomized Clinical Trial.

JAMA network open·2026
Same journal

Prefrontal Transcranial Pulse Stimulation for Major Depressive Disorder: A Randomized Clinical Trial.

JAMA network open·2026
See all related articles

Related Experiment Video

Updated: Mar 18, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

15.9K

Treating Opioid Use Disorder With Methadone in Pharmacies.

Cynthia A Tschampl1, Sage R Feltus2, Elena Soranno1

  • 1The Heller School for Social Policy and Management, Brandeis University, Waltham, Massachusetts.

JAMA Network Open
|March 16, 2026
PubMed
Summary
This summary is machine-generated.

Two pharmacy models for dispensing methadone (medication for opioid use disorder) show positive returns on investment. Expanding access to this life-saving medication can be profitable for community pharmacies.

More Related Videos

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

10.4K
Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.9K

Related Experiment Videos

Last Updated: Mar 18, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

15.9K
High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

10.4K
Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.9K

Area of Science:

  • Pharmacology and Public Health
  • Health Economics
  • Pharmacy Practice

Background:

  • Methadone is crucial for treating opioid use disorder but is underutilized in the US.
  • Current federal law limits methadone dispensing primarily to Opioid Treatment Programs (OTPs).
  • Pharmacy-based models could increase methadone access and improve overdose crisis response.

Purpose of the Study:

  • To evaluate the financial viability and return on investment (ROI) of two pharmacy-based methadone dispensing models.
  • To analyze the profitability of community pharmacies offering methadone services.

Main Methods:

  • A cross-sectional economic evaluation comparing two models: a medication unit within a pharmacy and direct pharmacist dispensing.
  • Models included startup and 3-year operational costs and revenues, using data from interviews, time-motion studies, and literature.
  • 10,000 Monte Carlo simulations were performed to determine ROI ratios and net profits with 95% uncertainty intervals.

Main Results:

  • The medication unit model yielded a 3-year ROI of $3.53 for every $1.00 spent, with a net profit of $96,904.
  • The pharmacist-dispensed model showed a 3-year ROI of $2.64 for every $1.00 spent, with a net profit of $23,844.
  • Both models demonstrated a high likelihood (over 93%) of achieving a $15,000 profit within 3 years.

Conclusions:

  • Both evaluated pharmacy-based methadone models are financially profitable over three years.
  • Increased access to methadone through pharmacies can be a viable business strategy.
  • Potential regulatory changes could facilitate broader implementation of these pharmacy-based models.