Related Experiment Video
Updated: Mar 18, 2026
Establishing a Mouse Model of Thin Endometrium
Published on: November 1, 2024
Effect of zero-time exercise intervention on endometrial receptivity in women with thin endometrium a single-center
Zhaohui Jiang1, Yanjiao Hua1, Li Deng1
1Department of Reproductive Medicine, The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530218, Guangxi Zhuang Autonomous Region, China.
Background:
Current therapeutic strategies for thin endometrium have inherent limitations, and zero-time exercise (ZTEx), a professionally guided fragmented low-intensity exercise, may serve as a novel adjunctive intervention for its management.
Methods:
This was a single-center randomized sham-controlled trial. Eligible patients undergoing ART were randomly divided into an experimental group (receiving ZTEx intervention) and a control group (receiving sham intervention). The ZTEx intervention was delivered over 12 weeks, featuring fragmented, low-intensity exercises under professional guidance. Key indicators of endometrial health-including endometrial thickness and endometrial receptivity-related parameters-were monitored throughout the intervention period.
Results:
After 12 weeks of intervention, ANCOVA (adjusted for baseline values) revealed that the experimental group had a significantly greater endometrial thickness than the control group (6.67 ± 1.15 mm vs. 5.88 ± 1.17 mm, P < 0.001). Concurrently, multiple endometrial receptivity-related indices improved significantly in the experimental group (all P < 0.05), including uterine artery hemodynamic parameters (pulsatility index [PI], resistance index [RI], systolic/diastolic ratio [S/D]) and vascularization indices (vascularization index [VI], flow index [FI], vascularization-flow index [VFI]).No exercise-related adverse events were reported over the course of the trial, confirming the safety profile of ZTEx.
Conclusions:
Supported by rigorous statistical analyses, ZTEx effectively enhances endometrial thickness and receptivity in ART patients with thin endometrium. Its key advantages-safety, feasibility, and no need for additional time or equipment-make it a promising adjuvant intervention in clinical ART settings.
