Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Mar 18, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

1.0K

Multi-institutional evaluation of prostate specific antigen dynamics after simple prostatectomy.

Austin J Livingston1, Daniel Segal2, Sarah Attia2

  • 1Department of Urology, Duke University Medical Center, P.O. Box 3831, Durham, NC, 27710, USA. Austin.livingston@duke.edu.

World Journal of Urology
|March 16, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Initial Experience with Sodium Acetate as a Renoprotective Agent During Robotic Partial Nephrectomy.

Journal of endourology·2026
Same author

Delayed Removal of the Noninfected Artificial Urinary Sphincter Has Comparable Outcomes to Immediate Removal.

Urology·2026
Same author

Enhancer-directed gene delivery for digit regeneration based on conserved epidermal factors.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

A fragment of 12S seed storage protein of Arabidopsis forms twisted cross beta-sheet rich amyloid fibrils.

International journal of biological macromolecules·2026
Same author

Enhancer-directed gene delivery for digit regeneration based on conserved epidermal factors.

bioRxiv : the preprint server for biology·2026
Same author

Multi-Institutional evaluation of bladder elongation psoas hitch (BEPH): a safe and durable solution for mid to distal ureteral strictures.

World journal of urology·2026

Prostate cancer (PCa) screening after simple prostatectomy (SP) is challenging. Postoperative PSA levels and velocity can help identify men at risk for PCa, with an initial PSA >1 ng/mL potentially triggering further screening.

Area of Science:

  • Urology
  • Oncology
  • Medical Diagnostics

Background:

  • Men undergoing simple prostatectomy (SP) for benign conditions remain at risk for prostate cancer (PCa).
  • Current prostate-specific antigen (PSA) surveillance guidelines after SP are lacking, making PCa detection difficult.
  • Differentiating benign from malignant pathology post-SP based on PSA is crucial for timely intervention.

Purpose of the Study:

  • To compare initial postoperative PSA levels and PSA kinetics in patients with benign prostate hyperplasia (BPH) versus those diagnosed with PCa after SP.
  • To identify potential PSA thresholds for triggering further PCa investigation in the post-SP setting.

Main Methods:

  • Retrospective review of 296 patients who underwent SP at two US tertiary care centers (2014-2022).
Keywords:
benign prostate hyperplasiaprostate cancersimple prostatectomy

More Related Videos

Retzius-Sparing Robot-Assisted Radical Prostatectomy
12:10

Retzius-Sparing Robot-Assisted Radical Prostatectomy

Published on: May 19, 2022

9.7K
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

17.3K

Related Experiment Videos

Last Updated: Mar 18, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

1.0K
Retzius-Sparing Robot-Assisted Radical Prostatectomy
12:10

Retzius-Sparing Robot-Assisted Radical Prostatectomy

Published on: May 19, 2022

9.7K
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

17.3K
  • Collected preoperative and postoperative PSA values, patient demographics, and oncologic diagnosis.
  • Categorized patients into BPH alone or PCa diagnosis groups (pre-existing or incidental).

    • Main Results:

    • No significant difference in preoperative PSA between BPH and PCa groups.
    • Initial postoperative PSA was significantly higher in the PCa group (1.37 ng/mL) compared to the BPH group (0.72 ng/mL).
    • PSA reduction was less in the PCa cohort (78%) vs. BPH (89%). Postoperative PSA velocity was significantly elevated in the PCa group (0.40 ng/mL/year vs. 0.004 ng/mL/year).

    Conclusions:

    • Initial postoperative PSA levels (at 3 months) and PSA velocity after SP can aid in identifying men at risk for PCa.
    • An initial postoperative PSA >1 ng/mL may warrant further PCa screening.
    • Larger studies are needed to establish definitive PSA cutoff values for post-SP PCa surveillance.