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Aquisinoids A and B: Two New Sesquiterpenoid-Benzaldehyde Hybrids From Aquilaria Sinensis
Li-Fen Ma1,2, Rong Huang2, Zhen-Zhou Han2
1School of Pharmacy, Guizhou Medical University, Guiyang, People's Republic of China.
Abstract:
Two previously undescribed sesquiterpenoid-benzaldehyde hybrids, aquisinoids A (1) and B (2), were isolated from agarwood of Aquilaria sinensis. Their structures were elucidated by comprehensive spectroscopic data analysis, single-crystal x-ray diffraction, and electronic circular dichroism calculations. Structurally, both compounds feature a polycyclic core formed by connecting a prezizaane-type sesquiterpenoid unit with a p-hydroxybenzaldehyde moiety via a 1,3-dioxolane bridge. Compounds 1 and 2 exhibited moderate inhibition on nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages, with IC50 values of 22.4 and 26.7 µM, respectively.
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