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Updated: Mar 18, 2026

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

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Published on: April 18, 2019

Improved Method for PFAS in Environmental Waters.

Amanda N Belunis¹, William R LaCourse¹

¹Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA.

Journal of Chromatographic Science

|March 16, 2026

Summary

This summary is machine-generated.

A new liquid chromatography tandem mass spectrometry method efficiently analyzes 40 per- and polyfluoroalkyl substances (PFAS) in water. This reliable method meets regulatory needs and detected seven PFAS in Baltimore-area water samples.

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Area of Science:

Environmental Chemistry
Analytical Chemistry

Background:

Per- and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants.
Growing public concern necessitates advanced analytical methods for PFAS detection and regulation compliance.

Purpose of the Study:

To develop an efficient, sensitive, and robust liquid chromatography tandem mass spectrometry (LC-MS/MS) method for analyzing 40 PFAS in aqueous matrices.
To compare automated and manual solid-phase extraction (SPE) techniques for improved sample recovery.

Main Methods:

Development of a 10-minute LC-MS/MS method for 40 PFAS.
Validation of linearity (r² > 0.997), limits of detection (0.2-100 ng/L), and quantification (1-350 ng/L).
Comparison of automated vs. manual SPE for recovery accuracy and precision.

Main Results:

The method demonstrated excellent linearity and sensitivity, meeting regulatory requirements.
Automated SPE yielded higher recoveries (92.0%-105.0%) compared to manual SPE (67.0%-109.0%).
Seven out of 40 PFAS compounds were detected in natural water samples from the Baltimore-Metro area.

Conclusions:

The developed LC-MS/MS method is efficient, sensitive, and reliable for PFAS analysis in water.
Automated SPE enhances sample recovery, improving method robustness.
The method is suitable for monitoring PFAS levels to comply with environmental regulations.