Mechanisms of glymphatic system dysfunction in central nervous system diseases

In recent years, with the continuous development of scientific and technological means, human understanding of previously unknown or insufficiently recognized physiological structures is gradually being decrypted, and the exploration of the causes of disease occurrence and development has become more thorough. As a newly discovered intracranial material transport system, the glymphatic system is named after its similarity to the lymphatic circulatory system. Its structure and function are gradually being understood, and its mechanism of action in central nervous system diseases is constantly being explored. More and more studies have confirmed the important relationship between glymphatic system dysfunction and central nervous system diseases from human, animal, and cell dimensions, and more and more evidence has revealed that regulating glymphatic system function is helpful to treat central nervous system diseases from behavior, imaging, pathology, and molecule. Therefore, this paper will review the glymphatic system from three aspects: structure, function, and mechanism in central nervous system diseases, with the intention of elaborating the mechanism of glymphatic system dysfunction in central nervous system diseases, and then contributing to its further research and exploration.