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Updated: Mar 18, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
High-grade follicular B-cell lymphoma-associated C3 rapidly progressive glomerulonephritis: a rare association
Jorge Raul Vazquez Urrutia1, Anne-Laure Strong2, Jozef Malysz3
1Department of Medicine, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania, USA jvazquezurrutia@pennstatehealth.psu.edu.
Abstract:
Rapidly progressive glomerulonephritis (GN) in the context of B-cell lymphoma is rare, with most cases involving diffuse-large B-cell lymphoma or marginal zone lymphoma. Kidney biopsies are infrequently performed in this population, further limiting diagnostic clarity. Here, we report a case of newly diagnosed follicular large B-cell lymphoma (FLBCL) presenting with a nephritic syndrome, characterised by haematuria, hypertension and heavy proteinuria, caused by C3 crescentic GN, requiring dialysis. The patient was treated with polatuzumab, bendamustine and rituximab, which was well tolerated. Renal function gradually improved, leading to dialysis discontinuation, coinciding with lymphoma remission. This case underscores the atypical presentation of FLBCL, including renal dysfunction as an early manifestation, and the importance of prompt diagnosis and targeted therapy.
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