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Updated: Mar 18, 2026
Human Cartilage Tissue Fabrication Using Three-dimensional Inkjet Printing Technology
Published on: June 10, 2014
[Application of Kartogenin in cartilage tissue engineering]
Jinhang Jiang1, Shujiang Zhang1, Weijie Lu1
1Department of Orthopedics, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Guangdong, 510120, P. R. China.
Objective:
To review the research progress and application prospects of Kartogenin (KGN) in cartilage repair and tissue engineering.
Methods:
Through a literature review, the mechanisms of KGN in cartilage repair, biomaterial composite strategies, and the resulting repair effectivenes were sorted out.
Results:
KGN regulates multiple signaling pathways to induce mesenchymal stem cells differentiation into chondrocytes, maintain chondrocyte phenotypes, inhibit chondrocyte senescence, and promote the secretion of extracellular matrix. KGN also forms high-efficiency scaffolds with various materials, suitable for tissue engineering scaffolds of different anatomical sites and defect types, and exhibits significant cartilage regenerative effectiveness in vitro and small animal models.
Conclusion:
Overall, KGN shows great application potential in cartilage tissue engineering. However, clinical translation still faces many challenges, which represents a key direction for future research.
