Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

56
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
56
CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

948
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
948
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

119
Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
119
Toxidromes: Clinical Features01:30

Toxidromes: Clinical Features

90
Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
90
Drug Therapy01:28

Drug Therapy

376
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
376
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

1.4K
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A latent profile analysis of opioid-related knowledge, social relationships, and campus connectedness among college students.

Frontiers in public health·2026
Same author

Young Adults' Perspectives on an Ecological Momentary Intervention for Drinking to Cope: Qualitative Study.

JMIR formative research·2026
Same author

Using the Consolidated Framework for Implementation Research (CFIR) to explore mutual-help group implementation challenges in college recovery programs.

BMC health services research·2026
Same author

Prevalence and clinical correlates of frailty among adults with HIV infection and unhealthy alcohol or drug use.

AIDS (London, England)·2026
Same author

HIV-related Stigma and Alcohol Involvement Among People with HIV Who Engage in Unhealthy Drinking.

AIDS and behavior·2026
Same author

Association of Continuous Medicaid Eligibility With Postpartum Coverage and Opioid Use Disorder Treatment.

American journal of preventive medicine·2026

Related Experiment Video

Updated: Mar 18, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

10.4K

Too Many Pills, Too Little Attention: Emphasizing Psychotropic Polypharmacy in the Overdose Conversation.

Madeline B Benz, Michael D Stein, Camille Clifford

    Journal of Addiction Medicine
    |March 17, 2026
    PubMed
    Summary
    This summary is machine-generated.

    Psychotropic polypharmacy, the use of multiple psychiatric drugs, is an underappreciated factor in the US overdose crisis. Addressing this issue is crucial for reducing high overdose mortality rates.

    Keywords:
    overdosepolypharmacypublic health crisis

    More Related Videos

    Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
    11:14

    Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry

    Published on: October 2, 2016

    12.2K
    Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
    06:06

    Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

    Published on: February 5, 2018

    27.0K

    Related Experiment Videos

    Last Updated: Mar 18, 2026

    High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
    10:17

    High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

    Published on: April 23, 2019

    10.4K
    Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
    11:14

    Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry

    Published on: October 2, 2016

    12.2K
    Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
    06:06

    Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

    Published on: February 5, 2018

    27.0K

    Area of Science:

    • Public Health
    • Psychiatry
    • Pharmacology

    Background:

    • The United States faces the highest global overdose mortality rate, with polysubstance use identified as a major contributor.
    • A decline in overdose deaths has been observed, yet the crisis persists, necessitating further investigation into contributing factors.

    Purpose of the Study:

    • To highlight psychotropic polypharmacy as a distinct and underappreciated issue in the overdose epidemic.
    • To emphasize the role of co-use of multiple psychiatric medications in overdose deaths and prevention strategies.

    Main Methods:

    • This commentary reviews existing evidence and proposes mechanisms linking psychotropic polypharmacy to increased overdose risk.
    • It synthesizes data on the prevalence of psychiatric polypharmacy and its association with overdose fatalities.

    Main Results:

    • Psychotropic polypharmacy increases overdose risk through drug-drug interactions, enhanced access to lethal means in suicidal individuals, and desensitization to overdose behaviors.
    • High rates of psychiatric polypharmacy in the US are linked to increasing overdose deaths involving prescription psychiatric medications.

    Conclusions:

    • Psychotropic polypharmacy is a critical, yet overlooked, factor in the ongoing overdose epidemic.
    • Solutions include deprescribing unnecessary medications, expanding non-pharmacological prevention, and enhancing overdose surveillance systems.