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Potential Risks of Blocking GDF15-Based Brain Energy Sensing
Alan A Cohen1,2, Martin Picard2,3
1Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.
Journal of the American Geriatrics Society
|March 17, 2026
Abstract:
GDF15 signals energetic stress to the brain, leading to unpleasant symptoms as the body conserves and reallocates energy. In conditions such as frailty and cancer, suppression of GDF15 signaling is expected to lead to an improvement in symptoms, but potentially at the cost of long-term health and survival.

