Related Experiment Video
Updated: Mar 18, 2026
07:27
Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
Published on: August 25, 2021
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Fall-related open globe injuries are associated with systemic health changes
Ryan S Meshkin1,2, Eric T Strand3, Grayson W Armstrong1,2
1Department of Ophthalmology, Massachusetts Eye and Ear, Boston, MA, USA.
Eye (London, England)
|March 17, 2026
Summary
Falls leading to open globe injuries (OGIs) often signal underlying health issues, including new diagnoses, worsening chronic conditions, or medication changes. A comprehensive systemic evaluation is crucial for timely management of these serious non-ophthalmic conditions.
Area of Science:
- Ophthalmology
- Geriatrics
- Internal Medicine
Background:
- Fall-related open globe injuries (OGIs) are a significant cause of vision loss.
- Systemic health changes preceding or following OGIs are not well characterized.
- Understanding these systemic factors is crucial for comprehensive patient care.
Purpose of the Study:
- To characterize peri-injury systemic health changes in patients with fall-related open globe injuries (OGIs).
- To identify potential contributing factors to falls in this patient population.
- To assess the association between systemic conditions and OGI outcomes.
Main Methods:
- Retrospective cohort study.
- Included 162 patients with fall-related OGIs from a larger cohort of 1016 OGIs.
- Reviewed electronic medical records for systemic diagnoses, disease exacerbations, medication changes, specialist visits, and mortality within 90 days of injury.
Main Results:
- Over 63% of patients had a new systemic diagnosis likely contributing to the fall.
- 26.5% experienced exacerbation of pre-existing conditions, often fall-related.
- Medication changes and specialist visits for non-ocular conditions were common, with significantly increased one-year mortality in older age groups.
Conclusions:
- Fall-related OGIs frequently occur alongside new or worsening systemic illnesses and medication changes.
- These injuries can serve as sentinel events indicating underlying health deterioration.
- Integrated systemic evaluation at OGI presentation is vital for managing serious non-ophthalmic conditions and improving patient outcomes.
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