Related Experiment Video
Updated: Mar 18, 2026

09:09
Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens
Published on: February 24, 2021
3.4K
Breaking barriers: A communication bundle for penicillin allergy label removal
Katie Ray1, Khaled Al-Zubaidi2, Sarah Seward3
1From the Department of Quality & Health Outcomes, Children's Wisconsin, Milwaukee, Wisconsin.
Allergy and Asthma Proceedings
|March 17, 2026
Summary
Direct communication via electronic faxing successfully reduced penicillin allergy labels in pharmacy records. This streamlined approach improved allergy removal rates, demonstrating effective inter-healthcare system collaboration.
Area of Science:
- * Clinical Informatics
- * Pharmacovigilance
- * Health Communication
Background:
- * Challenges persist in disseminating successful penicillin allergy delabeling outcomes.
- * Preventing penicillin allergy relabeling remains a significant clinical issue.
Purpose of the Study:
- * To evaluate the impact of direct electronic communication on penicillin allergy delabeling.
- * To assess the effectiveness of electronic faxing in preventing allergy relabeling.
Main Methods:
- * Utilized electronic faxing for direct communication of successful oral penicillin challenges.
- * Targeted outpatient pharmacies and out-of-network primary care providers.
- * Implemented a streamlined, bundled communication approach.
Main Results:
- * Penicillin allergy label presence in pharmacy records decreased from 32% to 12% (p < 0.001).
- * Allergy removal rates improved to 90% for out-of-network providers when combined with conventional methods (p = 0.029).
Conclusions:
- * Direct, reliable, and time-efficient communication between healthcare systems and pharmacies is feasible.
- * A streamlined, bundled approach enhances the success of allergy delabeling initiatives.
Related Concept Videos
Allergic Drug Reactions
1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Allergic Reactions: Anaphylaxis
118
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
118
Drug Toxicity: Allergic Reactions
104
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
104
Allergic Reactions
33.3K
Overview
33.3K
Pharmacovigilance
1.9K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.9K
Cross-reactivity
33.7K
Overview
33.7K

