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LAMB1 regulates COL3A1 and RAC1 expression during subchorionic hemorrhage progression.

Qian Sun1,2, Xiaoyan Wu1,2, Xiaopei Li1

  • 1Department of Gynecology, The First People's Hospital of Lianyungang, No. 6, Zhenhua Road, Haizhou District, Lianyungang, Jiangsu Province, 222061, China.

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|March 17, 2026
PubMed
Summary
This summary is machine-generated.

Laminin subunit β1 (LAMB1) drives subchorionic hemorrhage (SCH) by promoting inflammation and coagulation issues. Targeting LAMB1 could improve early diagnosis and treatment for better pregnancy outcomes in SCH patients.

Keywords:
Cell InvasionCell MigrationCell ProliferationIII CollagenInflammationInflammatory CytokinesRac Family Small GTPase 1Subchorionic Hemorrhage

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Area of Science:

  • Reproductive biology
  • Immunology
  • Molecular biology

Background:

  • Subchorionic hemorrhage (SCH) presents as a hypoechoic area in early pregnancy, impacting pregnancy outcomes.
  • The role of laminin subunit β1 (LAMB1) in SCH-associated coagulation and immune responses remains unclear.

Purpose of the Study:

  • To investigate the role of LAMB1 in subchorionic hemorrhage (SCH).
  • To elucidate the mechanisms by which LAMB1 modulates type III collagen (COL3A1) and Rac family small GTPase 1 (RAC1) in SCH.

Main Methods:

  • Proteomic and transcriptomic analyses of decidua and villous tissues from SCH patients and controls.
  • Bioinformatics and machine learning for biomarker screening.
  • In vivo (rat model) and in vitro (trophoblast cells) experiments to assess LAMB1 function.

Main Results:

  • LAMB1 was identified as a central protein in SCH, with its expression upregulated alongside COL3A1 and downregulated RAC1.
  • LAMB1 knockdown in vivo reduced inflammation and improved pregnancy outcomes, while in vitro, LAMB1 silencing enhanced trophoblast function.
  • LAMB1 was found to promote inflammation and coagulation dysfunction via the COL3A1/RAC1 axis.

Conclusions:

  • LAMB1 plays a critical role in promoting inflammation and coagulation dysfunction in subchorionic hemorrhage.
  • Targeting LAMB1 presents a potential novel therapeutic strategy for improving pregnancy outcomes in SCH.