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Investigating the Association Between Oral Hygiene and Oral Cancer: A Systematic Review and Meta-Analysis.
Lorena C Mariano1, Saman Warnakulasuriya2, Beatrice Lauby-Secretan3
1UNIPRO, Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS-CESPU), Gandra, Portugal.
Oral Diseases
|March 17, 2026
Summary
Poor oral hygiene, including infrequent toothbrushing and infrequent dental check-ups, significantly increases oral cancer risk. Brushing twice daily and annual dental visits may help reduce this risk.
Area of Science:
- Oral Health Research
- Oncology
- Preventive Medicine
Background:
- Oral hygiene practices are crucial for overall health.
- The link between oral hygiene and oral cancer risk requires further investigation.
Purpose of the Study:
- To investigate the association between toothbrushing frequency, dental check-up regularity, and oral cancer risk.
- To synthesize existing evidence through a systematic review and meta-analysis.
Main Methods:
- Systematic review and meta-analysis adhering to PRISMA and MOOSE guidelines.
- Comprehensive search of electronic databases until December 4, 2024.
- Inclusion of 15 relevant studies.
Main Results:
- Poor oral hygiene habits are identified as potential risk factors for oral cancer.
- Infrequent toothbrushing (less than once daily or never) significantly increased oral cancer risk (OR, 1.85).
- Less frequent toothbrushing (less than twice daily) and irregular dental check-ups (less than annually) were also associated with increased oral cancer risk.
Conclusions:
- Infrequent toothbrushing and irregular dental check-ups are confirmed risk factors for oral cancer.
- Recommendations include brushing teeth twice or more daily and annual dental visits to mitigate oral cancer risk.
- This study underscores the importance of maintaining good oral health for oral cancer prevention.
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