Related Experiment Video

Updated: Jun 16, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

SLE-diseaseome: a comprehensive meta-collection of systemic lupus erythematosus relevant functional pathways

Daniel Toro-Domínguez1,2, Chang Wang2, Iván Ellson-Lancho3

  • 1Unit of Inflammatory Diseases, Department of Environmental Medicine, Karolinska Institute, Solna, 171 77, Sweden.

Bioinformatics Advances
|March 17, 2026
PubMed
Abstract

Insights

Systemic lupus erythematosus (SLE) is complex due to varied patient pathways. We developed SLE-diseaseome, a novel resource of gene sets to better understand SLE pathogenesis and guide precision medicine approaches.

Area of Science:

  • Genomics
  • Systems Biology
  • Immunology

Background:

  • Systemic lupus erythematosus (SLE) presents diverse clinical manifestations and high treatment failure rates.
  • Disease heterogeneity, driven by dysregulated molecular pathways, complicates effective treatment strategies.
  • Precision medicine offers a promising approach by considering individual molecular disease mechanisms.

Purpose of the Study:

  • To address the lack of systemic understanding of pathways involved in SLE pathogenesis.
  • To create a comprehensive resource for functional interpretation of molecular data in SLE.
  • To facilitate precision medicine by characterizing molecular footprints of disease states.

Main Methods:

  • Developed an integrative, multi-cohort collection of disease-relevant functional gene sets termed SLE-diseaseome.
  • Integrated knowledge from multiple pathway databases and signature sources.
  • Robustly defined gene signatures by combining data from several studies.

Main Results:

  • Created the SLE-diseaseome, a curated collection of SLE-specific gene signatures.
  • The resource provides reliable and extensive reference signatures for functional interpretation.
  • Enables a more systemic understanding of pathways driving SLE pathogenesis.

Conclusions:

  • The SLE-diseaseome resource aids in understanding SLE heterogeneity and pathogenesis.
  • This resource supports the functional interpretation of molecular data for clinical studies.
  • Facilitates advancements in precision medicine for systemic lupus erythematosus.

More Related Videos

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...