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Updated: Mar 18, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Visible-Light-Driven Radical Amination/Cyclization of Arylethynyl Quinazolinones To Access Sulfonaminated
Qiyang Liu1, Jinwei Yuan1, Jianning Zhang1
1School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China.
Abstract:
A visible-light-driven radical amination/cyclization of arylethynyl quinazolin-4(3H)-ones was developed using N-aminopyridinium salts as sulfonamino radical precursors. A series of sulfonaminated quinolino[2,1-b]quinazolines were successfully synthesized under oxidant- and additive-free conditions. The transformation features a broad substrate scope, good to excellent yields, and mild reaction conditions. Notably, the amination-cyclization reaction could proceed smoothly under natural sunlight irradiation.
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