Related Experiment Video
Updated: Mar 25, 2026

Atom Transfer Radical Polymerization of Functionalized Vinyl Monomers Using Perylene as a Visible Light Photocatalyst
Published on: April 22, 2016
A mechanochemical construction of C-P bonds through radical-radical coupling
Ruizhi Sun1, Juxin Jiang1, Wenhao Li1
1School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, Shandong, 255000, P. R. China. lizhizhangsdut@foxmail.com.
Abstract:
Aryl phosphorus compounds are indispensable motifs in organic synthesis, medicinal, and materials chemistry. Herein, we report a robust magnesium-mediated mechanochemical protocol for the room-temperature synthesis of aryl phosphine oxides through direct C-P bond formation. The reaction employs phosphoryl chlorides with aryl or alkyl halides under solvent-minimized milling conditions, providing a broad range of products in moderate to high yields. Preliminary mechanistic investigations suggest that the transformation proceeds through a radical-radical cross-coupling pathway.
More Related Videos
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
Published on: June 20, 2014
11:44Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
Published on: March 20, 2014
Related Concept Videos
Radical Reactivity: Overview
Radical Formation: Addition
Similar to charge conservation in chemical reactions, spin conservation is implicit for radical reactions. Accordingly, the product formed must possess an...
Radical Formation: Overview
Radicals from spin-paired molecules:
Radicals can be obtained from spin-paired molecules either by homolysis or electron transfer. While two radicals are formed in the former, an electron is added in the...
Radical Formation: Homolysis
Radical Formation: Elimination
Radical Chain-Growth Polymerization: Mechanism