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Updated: Mar 24, 2026
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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
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Advanced Optical Sensing Techniques for Biomolecular Detection in the Human Body: Principles, Technologies, and
Mogal Mahazira Tabassum1, Yesudasu Vasimalla1, Ragini Singh2
1Centre of Excellence for Nanotechnology, Department of Electronics and Communication Engineering, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh, India.
Chemical Record (New York, N.Y.)
|March 17, 2026
Summary
Optical biosensing offers rapid, sensitive detection of biomolecules. Recent advances in nanophotonics and AI are paving the way for affordable, non-invasive point-of-care diagnostics.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Analytical Chemistry
Background:
- Optical biosensing platforms enable rapid and sensitive detection of diverse biomolecular targets.
- Key modalities include surface plasmon resonance (SPR), surface-enhanced Raman scattering (SERS), fluorescence, and interferometric sensors.
- Current limitations involve controlled lab environments, complex instrumentation, and high costs.
Purpose of the Study:
- To critically review principles, technological advances, and clinical potential of optical biosensing modalities.
- To highlight recent progress in nanophotonics, 2D materials, and microscale integration.
- To discuss the integration of AI and IoMT for enhanced diagnostics and monitoring.
Main Methods:
- Review of scientific literature on optical biosensing technologies.
- Analysis of breakthroughs in label-free detection, real-time monitoring, and miniaturization.
- Examination of emerging trends like nanophotonics, 2D materials, and AI integration.
Main Results:
- Significant progress has been made in improving signal stability and device portability.
- Nanophotonics and microscale integration are narrowing the gap towards point-of-care diagnostics.
- AI and IoMT integration support automated data interpretation and continuous healthcare monitoring.
Conclusions:
- Gradual advances, rather than a revolution, are driving optical biosensing towards clinical validity.
- The focus is on developing affordable, non-invasive biomolecular diagnostics.
- Future directions emphasize improved device portability and data interpretation for real-world applications.
