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Updated: Mar 19, 2026
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Freezing Human ES Cells
Published on: October 12, 2006
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Egg freezing in transgender men.
Caiane Gabrielle Souza de Paula1, Paula Bruno Monteiro1, Raissa de Vasconcelos Cavalcanti1
1Unichristus Centro Universitário Christus. Fortaleza, CE, Brazil.
JBRA Assisted Reproduction
|March 17, 2026
Summary
Fertility preservation through egg cryopreservation shows promise for transgender men undergoing hormone therapy. While prolonged testosterone use may not definitively impact oocyte quality, long-term fertility effects require further investigation.
Area of Science:
- Reproductive Endocrinology
- Transgender Health
- Oncofertility
Background:
- Transgender men (assigned female at birth, identify as male) face potential fertility impacts from testosterone therapy and gender-affirming surgery.
- Hormone therapy can impair ovarian function, and surgery may lead to irreversible reproductive capacity loss.
- Fertility preservation is a crucial option for transgender men desiring biological children.
Purpose of the Study:
- To evaluate the effectiveness of fertility preservation in transgender men.
- To analyze ovarian response to hormonal stimulation in this population.
- To investigate the impact of hormone therapy duration on oocyte quality and quantity.
Main Methods:
- Systematic review of studies from 2015-2025 in English, Portuguese, and Spanish databases (PubMed, SciELO, LILACS) following PRISMA guidelines.
- Inclusion of case, cohort, cross-sectional, prospective, and retrospective studies; exclusion of reviews, animal studies, and out-of-scope articles.
- Analysis of 13 selected studies after initial identification of 404 articles and exclusion of duplicates and non-relevant papers.
Main Results:
- Egg cryopreservation demonstrated promising outcomes for transgender men, even with extended testosterone therapy (2-12 years).
- Data suggests potential viability of oocytes despite prolonged hormone use, though definitive conclusions are pending.
- One patient lacked sufficient data for analysis due to no embryo transfer.
Conclusions:
- Fertility preservation, particularly egg cryopreservation, offers a viable reproductive alternative for transgender men.
- Prolonged testosterone therapy appears promising for preserving oocyte quality, but long-term fertility effects warrant further research.
- This review enhances understanding of reproductive options and outcomes for transgender men.
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