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Related Experiment Video

Updated: Mar 19, 2026

Freezing Human ES Cells

Freezing Human ES Cells

Published on: October 12, 2006

Egg freezing in transgender men.

Caiane Gabrielle Souza de Paula¹, Paula Bruno Monteiro¹, Raissa de Vasconcelos Cavalcanti¹

¹Unichristus Centro Universitário Christus. Fortaleza, CE, Brazil.

JBRA Assisted Reproduction

|March 17, 2026

Summary

This summary is machine-generated.

Fertility preservation through egg cryopreservation shows promise for transgender men undergoing hormone therapy. While prolonged testosterone use may not definitively impact oocyte quality, long-term fertility effects require further investigation.

Keywords:

cryopreservation fertility preservation hormone therapy oocyte quality transmasculine male

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Area of Science:

Reproductive Endocrinology
Transgender Health
Oncofertility

Background:

Transgender men (assigned female at birth, identify as male) face potential fertility impacts from testosterone therapy and gender-affirming surgery.
Hormone therapy can impair ovarian function, and surgery may lead to irreversible reproductive capacity loss.
Fertility preservation is a crucial option for transgender men desiring biological children.

Purpose of the Study:

To evaluate the effectiveness of fertility preservation in transgender men.
To analyze ovarian response to hormonal stimulation in this population.
To investigate the impact of hormone therapy duration on oocyte quality and quantity.

Main Methods:

Systematic review of studies from 2015-2025 in English, Portuguese, and Spanish databases (PubMed, SciELO, LILACS) following PRISMA guidelines.
Inclusion of case, cohort, cross-sectional, prospective, and retrospective studies; exclusion of reviews, animal studies, and out-of-scope articles.
Analysis of 13 selected studies after initial identification of 404 articles and exclusion of duplicates and non-relevant papers.

Main Results:

Egg cryopreservation demonstrated promising outcomes for transgender men, even with extended testosterone therapy (2-12 years).
Data suggests potential viability of oocytes despite prolonged hormone use, though definitive conclusions are pending.
One patient lacked sufficient data for analysis due to no embryo transfer.

Conclusions:

Fertility preservation, particularly egg cryopreservation, offers a viable reproductive alternative for transgender men.
Prolonged testosterone therapy appears promising for preserving oocyte quality, but long-term fertility effects warrant further research.
This review enhances understanding of reproductive options and outcomes for transgender men.