Related Experiment Video
Updated: May 5, 2026
07:43
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
20.0K
Prostate Cancer Leading Skull Metastasis With Papilledema.
Jiateng Lin1, Fangfang Wang1, Shancheng Si2
1Rongcheng Eye Hospital, Rongcheng.
The Journal of Craniofacial Surgery
|March 17, 2026
Summary
Prostate cancer (PCa) can present unusually in elderly men with skull thickening and papilledema. Early recognition of metastatic PCa is crucial for timely diagnosis and management.
Area of Science:
- Oncology
- Ophthalmology
- Neurosurgery
Background:
- Elderly men with chronic blurred vision may present with papilledema.
- Skull lesions can mimic benign conditions like fibrous dysplasia.
Purpose of the Study:
- To report a rare case of prostate cancer metastasis presenting as papilledema.
- To emphasize the importance of considering metastatic prostate cancer in elderly men with unexplained neurological and ophthalmological findings.
Main Methods:
- Case report of a 74-year-old man with chronic blurred vision.
- Diagnostic workup included ultra-widefield imaging, head CT, and histopathology.
- Biochemical markers (alkaline phosphatase, prostate-specific antigen) were analyzed.
Main Results:
- Papilledema and skull lesion were observed.
- Histopathology confirmed skull metastasis from prostate cancer.
- Elevated prostate-specific antigen and alkaline phosphatase were noted but initially overlooked.
Conclusions:
- Metastatic prostate cancer can present with papilledema and skull thickening in elderly men.
- Multidisciplinary collaboration is essential for accurate diagnosis and management.
- Consider metastatic prostate cancer in elderly men with unexplained papilledema and skull lesions.
Related Concept Videos
01:26Brain Abscess l: Introduction
21
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial...
21
01:14Increased Intracranial Pressure l: Introduction
27
Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component...
27
01:29Increased Intracranial Pressure ll: Pathophysiology
20
Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins...
20
01:22Cerebral Edema ll: Pathophysiology
19
Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this...
19