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Published on: March 28, 2013
Structure-guided identification of dipeptides modulating PPARα-associated lipid metabolism
Arata Banno1, Rana Yu1, Nanami Nishino1
1Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Gifu 501-1193, Japan.
None:
The structural basis for dipeptides modulating PPARα remains unclear. AlphaFold2 identified Ile-His as a candidate predicted to interact with a novel alternative binding site. In HepG2 cells, Ile-His and Phe-Ala reduced cholesterol accumulation, whereas Ala-Pro had no effect. These findings support the utility of structure-based prediction as a hypothesis-generating approach for identifying dipeptides associated with PPARα-related modulation of lipid metabolism.

