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Updated: Mar 19, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
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Severe renovascular hypertension in an infant with a SMAD3 gene variant

Marianna Lichosik1, Agata Błażejczyk2, Andrzej Biełanowicz2

  • 1Department of Nephrology, Kidney Transplantation and Hypertension, The Children's Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730, Warsaw, Poland.

Pediatric Nephrology (Berlin, Germany)
|March 17, 2026
PubMed

Insights

This case highlights a young boy with severe hypertension and left ventricle hypertrophy due to renal artery stenosis. Genetic testing identified a SMAD3 variant, emphasizing the need for early genetic evaluation in pediatric hypertension.

Area of Science:

  • Pediatric Cardiology
  • Medical Genetics
  • Nephrology

Background:

  • Renal artery stenosis is a significant cause of secondary hypertension in children.
  • This condition can lead to hypertension-mediated organ damage, such as left ventricle hypertrophy.
Abstract

Keywords:
SMAD3 variantHypertensionHypertension-mediated organ damageLeft ventricular hypertrophyRenal artery stenosis

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