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Related Concept Videos

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The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Microbiota of the Large Intestine01:27

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The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
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The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
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Related Experiment Video

Updated: Mar 19, 2026

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
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Ellagic acid can improve stroke by regulating gut microbiota.

Yiqin Xu1, Yong Zhang1, Min Huang1

  • 1Department of Histology and Embryology, School of Medicine, Shaoxing University, Shaoxing, Zhejiang Province, 312000, China.

Metabolic Brain Disease
|March 17, 2026
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Summary

Ellagic acid may improve stroke recovery by modulating the gut microbiota. Further research into drug delivery systems and derivatives is recommended to enhance its therapeutic potential for stroke patients.

Keywords:
Ellagic acidGut microbiotaMicrobiota-gut-brain axisStroke

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Area of Science:

  • Neuroscience
  • Microbiology
  • Pharmacology

Background:

  • Stroke leads to significant morbidity, mortality, and disability, necessitating improved rehabilitation strategies.
  • The microbiota-gut-brain axis is a key communication pathway implicated in stroke pathogenesis and gastrointestinal complications.
  • Gut microbiota dysbiosis is increasingly recognized as a factor influencing stroke development and prognosis.

Purpose of the Study:

  • To review the role of ellagic acid in modulating the gut microbiota for stroke recovery.
  • To analyze the in vivo metabolism, biological activities, and therapeutic potential of ellagic acid.
  • To identify strategies for overcoming ellagic acid's limitations, such as poor bioavailability.

Main Methods:

  • Systematic analysis of in vivo metabolism of ellagic acid.
  • Review of existing literature on ellagic acid, gut microbiota, and stroke.
  • Evaluation of ellagic acid's anti-inflammatory and antioxidant properties.

Main Results:

  • Ellagic acid demonstrates anti-inflammatory and antioxidant properties with potential to modulate gut microbiota.
  • In vivo metabolism studies elucidate key biological activities and therapeutic potentials of ellagic acid.
  • Limited bioavailability and solubility are identified as key limitations for ellagic acid's clinical application.

Conclusions:

  • Ellagic acid shows promise in ameliorating stroke outcomes through gut microbiota modulation.
  • Development of advanced drug delivery systems and novel ellagic acid derivatives can enhance efficacy.
  • Targeting the microbiota-gut-brain axis with ellagic acid offers a promising therapeutic strategy for stroke rehabilitation.