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Electrophysiological Measurements and Analysis of Nociception in Human Infants
Published on: December 20, 2011
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Intelligent system for infants' pain detection: pain intensity estimation using deep learning approach.
Mashhour Amer1, Manal Kassab2, Waed Alshurman3
1Department of Biomedical Engineering, Jordan University for Science and Technology, AR-Ramtha, Irbid, 3030, Jordan.
Physical and Engineering Sciences in Medicine
|March 17, 2026
Summary
This study introduces an Artificial Intelligence (AI) model to detect infant pain using facial expressions. The AI system accurately estimates pain levels, improving pain management for non-verbal infants in the NICU.
Area of Science:
- Medical technology
- Artificial Intelligence
- Neonatal care
Background:
- Traditional pain assessment tools for infants have limitations.
- Accurate pain detection is crucial for effective pain management in neonates.
- Artificial Intelligence offers novel approaches for objective pain assessment.
Purpose of the Study:
- To develop a deep learning model for estimating infant pain intensity (0-9) from facial expressions.
- To address limitations of traditional pain assessment methods in the NICU.
- To improve pain management for non-verbal infants.
Main Methods:
- A regression Convolutional Neural Network (CNN) model was developed.
- Transfer learning with a pre-trained VGG16 model was employed for fine-tuning.
- Facial expressions of full-term infants during NICU procedures were analyzed.
Main Results:
- The CNN model achieved a Mean Absolute Error (MAE) of 0.494 and Mean Squared Error (MSE) of 0.435.
- The model demonstrated good performance in estimating pain intensity.
- Transfer learning and fine-tuning helped improve model performance and avoid overfitting.
Conclusions:
- The proposed AI model accurately detects infant pain based on facial expressions.
- This technology can significantly aid healthcare professionals in providing effective pain management.
- Future work includes developing a portable, user-friendly web application for the system.

