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Risk factors associated with cardiac dysfunction in men with erectile dysfunction.

Emil Durukan1, Christian Fuglesang S Jensen1, Maria Dons2,3

  • 1Department of Urology, Copenhagen University Hospital-Herlev & Gentofte, Herlev, Denmark.

The Journal of Sexual Medicine
|March 17, 2026
PubMed
Summary

Erectile dysfunction (ED) is linked to cardiac dysfunction. Key risk factors include elevated body mass index (BMI), diastolic blood pressure, hemoglobin A1c (HbA1c), and dyslipidemia, highlighting the need for cardiovascular risk assessment in men with ED.

Keywords:
EchocardiographyLV systolic dysfunctioncardiac diseasecardiovascular diseaseclinical characteristicserectile dysfunctionrisk factors

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Area of Science:

  • Cardiology
  • Urology
  • Endocrinology

Background:

  • Erectile dysfunction (ED) is an early indicator of cardiovascular disease (CVD).
  • Specific clinical factors linking ED to cardiac dysfunction require clarification.

Purpose of the Study:

  • To identify risk factors for cardiac dysfunction in men with ED.
  • Utilize echocardiography to assess cardiac function in relation to ED.

Main Methods:

  • Cross-sectional study involving men with ED recruited from urology clinics and general population samples.
  • Echocardiography employed to evaluate left ventricular (LV) systolic and diastolic dysfunction.
  • Analysis of associations between cardiac dysfunction and clinical variables including BMI, blood pressure, HbA1c, and lipid profiles.

Main Results:

  • In multivariable analysis, elevated BMI, diastolic blood pressure, and HbA1c were significantly associated with LV systolic dysfunction.
  • BMI and dyslipidemia were identified as risk factors for LV diastolic dysfunction.
  • The study included 398 men, with detailed analysis of cardiometabolic risk factors.

Conclusions:

  • Cardiometabolic risk factors are associated with echocardiographic evidence of cardiac dysfunction in men with ED.
  • Findings underscore the importance of cardiovascular risk assessment and targeted prevention in men experiencing ED.
  • Elevated BMI, diastolic blood pressure, and HbA1c are linked to LV systolic dysfunction; BMI and dyslipidemia are associated with LV diastolic dysfunction.