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A lightweight and robust method for electrocardiogram anomaly detection and localization using multi-scale masked
Ya Zhou1, Yujie Yang1, Jianhuang Gan1
1Department of Information Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Plos One
|March 17, 2026
Summary
This study introduces MMAE-ECG, a novel method for electrocardiogram (ECG) anomaly detection. It efficiently identifies heart condition irregularities without complex preprocessing, offering a more robust and computationally cheaper alternative.
Area of Science:
- Biomedical Engineering
- Artificial Intelligence in Medicine
- Cardiology
Background:
- Electrocardiogram (ECG) analysis is vital for diagnosing cardiovascular diseases.
- Traditional methods often require extensive labeled data and complex preprocessing like R-peak detection.
- Anomaly detection offers a flexible approach for rare and diverse cardiac conditions.
Purpose of the Study:
- To develop an efficient and robust ECG anomaly detection method.
- To overcome the limitations of existing methods relying on complex preprocessing.
- To capture both global and local dependencies in ECG signals effectively.
Main Methods:
- Proposed MMAE-ECG, a multi-scale masked autoencoder.
- Integrated multi-scale masking and attention mechanisms with distinct positional embeddings.
- Utilized a lightweight Transformer encoder and an aggregation strategy for anomaly scoring.
Main Results:
- Achieved state-of-the-art performance in ECG anomaly detection and localization.
- Significantly reduced computational costs: ~1/78 inference FLOPs and 1/18 trainable parameters.
- Demonstrated the effectiveness of multi-scale strategies and aggregation for anomaly detection.
Conclusions:
- MMAE-ECG provides an effective and efficient solution for ECG anomaly detection.
- The multi-scale masked autoencoder approach eliminates the need for complex preprocessing steps.
- This method holds significant potential for improving cardiovascular diagnostics through automated ECG analysis.