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Negative Affect and Plasma Aldosterone in Working Adults.
William D Eckerle1, Bethany Barone-Gibbs, Thomas Kamarck
1Department of Psychology (Eckerle), Departments of Psychology and Psychiatry (Kamarck), Department of Medicine and Biostatistics (Perera), Department of Medicine, Division of Cardiology (Muldoon), University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Epidemiology and Biostatistics, West Virginia University, Morgantown, West Virginia (Barone-Gibbs).
Biopsychosocial Science and Medicine
|March 17, 2026
Summary
Negative affect, or psychological stress, was not associated with aldosterone levels in adults. Further research is needed to understand the link between mood and cardiovascular disease risk factors.
Area of Science:
- Cardiovascular Disease Research
- Psychoneuroendocrinology
- Human Physiology
Background:
- Psychological stress and negative affect are linked to increased cardiovascular disease (CVD) risk.
- The renin-angiotensin-aldosterone system (RAAS) is a potential mechanism, but its association with negative affect is unclear.
Purpose of the Study:
- To investigate the association between negative affect and plasma aldosterone concentrations.
- To test the hypothesis that higher negative affect correlates with higher aldosterone.
Main Methods:
- Analysis of baseline data from the RESET-BP trial.
- 193 adult participants (aged 24-65) assessed for negative affect using validated questionnaires.
- Measured plasma aldosterone concentrations.
Main Results:
- Correlational and regression analyses revealed no significant association between aldosterone and negative affect.
- This lack of association persisted even after controlling for demographic and anthropometric variables.
Conclusions:
- The study found no evidence that negative affect is directly related to aldosterone concentrations.
- Additional research is necessary to elucidate psychological mediators linking mood disorders and aldosterone.
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