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Microfluidic sensing technologies for exosome-based isolation, detection and therapy in panvascular diseases
Shiying Wang1, Jinghan Tian1, Liu Yang2
1School of Laboratory Medicine, Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan, 430065, China.
Biosensors & Bioelectronics
|March 17, 2026
Summary
Microfluidic biosensors offer advanced methods for isolating and detecting exosomes, crucial for diagnosing and treating panvascular diseases (PVDs). These technologies improve exosome analysis and therapeutic applications for systemic vascular disorders.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cardiovascular Research
Background:
- Panvascular diseases (PVDs) are systemic vascular disorders, primarily driven by atherosclerosis, causing widespread injury.
- Atherosclerotic lesions are prevalent, even in asymptomatic individuals, affecting multiple vascular beds and underscoring the need for early detection.
- Mammalian cell-derived exosomes show potential as biomarkers and drug delivery vehicles for PVDs, but face challenges like low abundance and heterogeneity.
Purpose of the Study:
- To provide a comprehensive review of microfluidic biosensor platforms for exosome applications in PVDs.
- To highlight the advantages of microfluidics in exosome isolation, detection, and therapeutic engineering.
- To discuss the potential of microfluidic technologies in advancing exosome-based diagnostics and therapeutics for PVDs.
Main Methods:
- Review of microfluidic strategies including size-exclusion and immunoaffinity capture.
- Discussion of integrated electrochemical and optical transduction methods for enhanced sensitivity.
- Exploration of microfluidic-enabled exosome cargo loading and surface functionalization.
Main Results:
- Microfluidic biosensors enhance analytical sensitivity, reduce sample volume, and improve throughput and reproducibility for exosome analysis.
- These platforms allow precise control over exosome modification for therapeutic engineering.
- Scalable and integrative microfluidic frameworks are being established for exosome-based diagnostics and therapeutics.
Conclusions:
- Microfluidic biosensors represent a significant advancement for exosome isolation, detection, and engineering in the context of PVDs.
- These technologies offer promising avenues for improved diagnostics and therapeutic strategies for systemic vascular disorders.
- Further development is needed in standardization, multiplexing, and clinical translation to fully realize the potential of these microfluidic platforms.
