Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

611
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
611
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

721
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
721

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic relevance and molecular correlates of Claudin-1 expression in pancreatic neuroendocrine tumors.

Human pathology·2026
Same author

Breaking news from ESMO 2025: liquid biopsy novelties in gastrointestinal cancer.

The journal of liquid biopsy·2026
Same author

SBRT plus abiraterone acetate and ADT versus abiraterone acetate and ADT in oligometastatic castrate-resistant prostate cancer (ARTO): long-term, unplanned overall survival analysis of an open-label, randomised, phase 2 trial.

The Lancet. Oncology·2026
Same author

MRI-Based Radiomics to Predict Response to Neoadjuvant Therapy in Locally Advanced Rectal Cancer: A Retrospective Study.

Journal of personalized medicine·2026
Same author

Clinical and pathological predictors of early recurrence after neoadjuvant cisplatin gemcitabine in muscle invasive bladder cancer in the RealBLADDER study.

Scientific reports·2026
Same author

Radiogenomics in Lymphoma and Multiple Myeloma: A Systematic Review of Current Evidence and Future Directions.

Journal of clinical medicine·2026
Same journal

<sup>18</sup>F-NaF PET/CT Versus <sup>18</sup>F-FDG PET/CT for Baseline Mapping in Ollier Disease: A Pediatric Case.

Journal of nuclear medicine technology·2026
Same journal

Incidental Detection of Aggressive HER2-Positive Breast Cancer on <sup>99m</sup>Tc-Sestamibi Parathyroid Scintigraphy.

Journal of nuclear medicine technology·2026
Same journal

Structured Educational Tours in Hospital-Based Radiopharmaceutical Production: Balancing Safety and Learning.

Journal of nuclear medicine technology·2026
Same journal

Development of a Phantom for Evaluating Image Quality and Partial-Volume Effects in Hot and Cold Regions in Small-Animal SPECT and PET.

Journal of nuclear medicine technology·2026
Same journal

Nonuniformity in a Certified <sup>68</sup>Ge PET Cylinder Phantom: Implications for Normalization Quality Assurance.

Journal of nuclear medicine technology·2026
Same journal

Reducing Formation of Suspected Tracer Microemboli During Preparation of <sup>99m</sup>Tc-Tagged Heat-Damaged Red Blood Cells.

Journal of nuclear medicine technology·2026
See all related articles

Related Experiment Video

Updated: Mar 19, 2026

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

10.6K

Radiomics on 177Lu-DOTATATE Posttreatment Scans: Feasibility, Preprocessing Optimization, and Planar-SPECT

Flavio Montanini1,2, Alessio Imperiale3,4, Alice Monaci5

  • 1Nuclear Medicine Unit, Careggi University Hospital, Florence, Italy; montaninif@aou-careggi.toscana.it.

Journal of Nuclear Medicine Technology
|March 17, 2026
PubMed
Summary
This summary is machine-generated.

Radiomic analysis of 177Lu-DOTATATE scans is feasible for neuroendocrine tumors (NETs). Normalizing intensity to the third lumbar vertebra (V-norm) is superior to spleen normalization (S-norm) for radiomic feature extraction.

Keywords:
177Lu-DOTATATENETPRRTposttreatment scanradiomics

More Related Videos

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

1.0K
Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
10:47

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

9.5K

Related Experiment Videos

Last Updated: Mar 19, 2026

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

10.6K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

1.0K
Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
10:47

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

9.5K

Area of Science:

  • Nuclear Medicine
  • Radiology
  • Oncology

Background:

  • 177Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) is a key treatment for neuroendocrine tumors (NETs).
  • Radiomics, the extraction of quantitative features from medical images, has been primarily developed using 68Ga-DOTATOC PET, leaving PRRT-related scintigraphy underexplored.
  • This study addresses the gap by investigating radiomic feature extraction from post-PRRT 177Lu-DOTATATE scans.

Purpose of the Study:

  • To evaluate the feasibility of extracting hepatic radiomic features from posttreatment whole-body planar scintigraphic (WBS) and SPECT scans.
  • To optimize preprocessing strategies for radiomic analysis of 177Lu-DOTATATE scans.
  • To compare radiomic profiles between WBS and SPECT imaging modalities.

Main Methods:

  • Retrospective analysis of 183 WBS and 108 SPECT scans from 49 patients with gastroenteropancreatic NETs undergoing 177Lu-DOTATATE PRRT.
  • Image-intensity normalization using spleen (S-norm) and third lumbar vertebra (V-norm) mean counts.
  • Radiomic feature extraction with 64-bin discretization and relative intensity rescaling, without spatial resampling.

Main Results:

  • Successful texture extraction from all WBS and SPECT images.
  • V-norm normalization showed more effective intensity normalization with lower variability compared to S-norm.
  • Robust correlations were found for histogram-based and second-order features between S-norm and V-norm, while intensity-based features showed weak correlations.
  • Intensity-based features correlated well between WBS and SPECT, but histogram-based and second-order features did not show significant correlation.

Conclusions:

  • Radiomic analysis of posttreatment 177Lu-DOTATATE scans is feasible.
  • Third lumbar vertebra normalization (V-norm) is the preferred method for intensity normalization due to reduced variability.
  • Radiomic features from WBS and SPECT are not directly comparable, except for intensity-based features.