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Updated: Mar 19, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
Exploiting cellular senescence in hematologic malignancies
Peijie Jiang1, Guancui Yang1, Jiarun Li1
1Chongqing Key Laboratory of Hematology and Microenvironment, Medical Center of Hematology, Second Affiliated Hospital, Army Medical University, Chongqing 40037, China.
Abstract:
Cellular Senescence is characterized by stable cell cycle arrest and major changes in cell morphology and physiology. Accumulating evidence indicates that senescence-associated phenotypic alterations in blood cells drive the initiation and progression of hematologic malignancies. Therefore, we reviewed the phenotypes associated with cellular senescence and the regulatory mechanisms of cellular senescence in hematological malignancies. Notably, chemical induction of cellular senescence and selectively elimination of senescent cells can effectively inhibit tumor cell proliferation and enhance the efficacy of chemotherapy. This review also discusses the role of cellular senescence in the treatment of hematological malignancies, providing an in-depth understanding of the role of cellular senescence as a double-edged sword in cancer biology.
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