Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.3K
Replicative Cell Senescence02:15

Replicative Cell Senescence

4.6K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.6K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.4K
3.4K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.8K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

4.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
4.1K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

7.3K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Exposure to Biomarker: Cumulative Tobacco Burden and Integrated Multiomics Signatures of High Tumor Mutational Burden in Lung Adenocarcinoma-A Secondary Analysis of the Cancer Genome Atlas.

Human mutation·2026
Same author

Prediction of incident atrial fibrillation from retinal fundus images using a multimodal foundation model.

NPJ digital medicine·2026
Same author

Hypoxia-driven T cell-macrophage-stromal cross-talk sustains fibrosis in preclinical models of cutaneous chronic graft-versus-host disease.

Science translational medicine·2026
Same author

Postoperative radiotherapy-induced pulmonary leiomyosarcoma in breast cancer: a case report and literature review.

Frontiers in oncology·2026
Same author

A wide-necked saccular aneurysm of the middle cerebral artery bifurcation with neck atherosclerosis mimicking a fusiform aneurysm: illustrative case.

Journal of neurosurgery. Case lessons·2026
Same author

Symmetry-Driven Multimodal Adversarial Attacks: An Information-Theoretic Perspective on Cross-Modal Invariance and Robustness.

Entropy (Basel, Switzerland)·2026

Related Experiment Video

Updated: Mar 19, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

18.3K

Exploiting cellular senescence in hematologic malignancies.

Peijie Jiang1, Guancui Yang1, Jiarun Li1

  • 1Chongqing Key Laboratory of Hematology and Microenvironment, Medical Center of Hematology, Second Affiliated Hospital, Army Medical University, Chongqing 40037, China.

Translational Oncology
|March 17, 2026
PubMed
Summary
This summary is machine-generated.

Cellular senescence, a state of stable cell cycle arrest, influences blood cell changes that drive hematologic malignancies. Targeting senescent cells offers a promising therapeutic strategy for these cancers.

Keywords:
Hematologic malignanciesSenescenceTherapy

More Related Videos

Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
08:56

Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells

Published on: July 12, 2022

3.6K
SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

25.4K

Related Experiment Videos

Last Updated: Mar 19, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

18.3K
Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
08:56

Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells

Published on: July 12, 2022

3.6K
SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

25.4K

Area of Science:

  • Oncology
  • Cell Biology
  • Hematology

Background:

  • Cellular senescence involves cell cycle arrest and altered cell characteristics.
  • Senescence-associated changes in blood cells contribute to hematologic malignancy development.
  • Understanding senescence mechanisms is crucial for cancer research.

Purpose of the Study:

  • To review senescence phenotypes and regulatory mechanisms in hematologic malignancies.
  • To explore the therapeutic potential of targeting cellular senescence in these cancers.
  • To elucidate the dual role of senescence in cancer biology.

Main Methods:

  • Literature review of cellular senescence in hematologic malignancies.
  • Analysis of senescence-associated phenotypic alterations in blood cells.
  • Examination of regulatory mechanisms controlling senescence.

Main Results:

  • Senescence phenotypes in blood cells are linked to hematologic malignancy initiation and progression.
  • Chemical induction of senescence and senescent cell elimination inhibit tumor growth.
  • Targeting senescent cells can enhance chemotherapy efficacy.

Conclusions:

  • Cellular senescence plays a complex, double-edged role in hematologic malignancies.
  • Modulating cellular senescence presents a potential therapeutic avenue for cancer treatment.
  • Further research into senescence mechanisms can optimize cancer therapies.