Methodology of SEEG functional mapping of the sensory-motor regions using electrical brain stimulation

Intracerebral electrical stimulation during stereoelectroencephalography (SEEG) is a key technique for functional mapping in the presurgical evaluation of patients with drug-resistant epilepsy. This article presents a concise anatomical overview and outlines standardized methodologies for SEEG-guided stimulation in motor, premotor, somatosensory, and operculo-insular regions. In these areas, functional stimulations are generally feasible under optimal conditions, yielding clear and reproducible clinical responses. We detail stimulation protocols, patient task paradigms, and the range of motor, sensory, and speech effects elicited, providing practical guidance for accurate and safe functional mapping in this eloquent cortex.