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Related Experiment Videos

Ethanol drinking by rhesus monkeys as a function of concentration.

J E Henningfield, R A Meisch

    Psychopharmacology
    |April 28, 1978
    PubMed
    Summary

    Rhesus monkeys maintained fixed-ratio responding for ethanol. Increasing ethanol concentration decreased liquid deliveries, with high blood ethanol levels observed.

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    Area of Science:

    • Pharmacology
    • Behavioral Neuroscience

    Background:

    • Ethanol self-administration is a key model for studying alcohol use disorders.
    • Understanding factors influencing ethanol intake is crucial for developing effective treatments.

    Purpose of the Study:

    • To investigate the effects of varying ethanol concentrations on fixed-ratio responding in rhesus monkeys.
    • To determine the relationship between ethanol concentration and intake under controlled conditions.

    Main Methods:

    • Three rhesus monkeys were trained to respond on a fixed-ratio schedule for ethanol access.
    • Ethanol concentration was systematically varied across sessions, with water as a control.
    • Blood ethanol levels were measured to assess systemic exposure.

    Main Results:

    • Fixed-ratio responding was maintained across tested ethanol concentrations.
    • Increasing ethanol concentration led to a modest decrease in the number of liquid deliveries.
    • Blood ethanol levels frequently exceeded 200 mg%, with some reaching over 300 mg%.

    Conclusions:

    • Rhesus monkeys will self-administer ethanol at concentrations leading to significant systemic exposure.
    • Response patterns can be modulated by ethanol concentration, suggesting dose-dependent effects on operant behavior.

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