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Reducing Hospital Readmissions for Injection Drug Use-Related Infections: A Rapid Qualitative Analysis of Health Care
Journal of Addiction Medicine
|March 18, 2026
Summary
People who inject drugs (PWID) face high rehospitalization risks. Integrated care and patient navigation interventions show promise for reducing readmissions by addressing care gaps and structural barriers.
Area of Science:
- Public Health
- Health Services Research
- Addiction Medicine
Background:
- People who inject drugs (PWID) experience high rates of hospitalization and readmission due to injection-related infections.
- Existing evidence-based interventions to prevent readmissions among PWID are limited.
Purpose of the Study:
- To explore factors contributing to rehospitalization among PWID.
- To identify potential strategies for preventing readmissions.
- To assess the acceptability and implementation considerations of two proposed interventions: integrated care and patient navigation.
Main Methods:
- Conducted 22 semistructured interviews with 36 healthcare providers and staff across four study sites.
- Purposive sampling ensured diverse representation of roles in PWID care.
- Employed rapid qualitative analysis informed by framework and thematic approaches.
Main Results:
- Key rehospitalization factors include unaddressed structural/social determinants, health system gaps, inadequate addiction care training, and poor continuity of care.
- Healthcare providers expressed high acceptability for both integrated care and patient navigation interventions.
- Implementation recommendations focus on organizational capacity, resource leveraging, and patient engagement/retention.
Conclusions:
- Reducing readmissions for PWID necessitates addressing provider training, care fragmentation, and structural barriers.
- Integrated care and patient navigation interventions are acceptable to healthcare teams.
- Successful implementation hinges on organizational capacity, resource optimization, and person-centered patient engagement.
Keywords:
CHOICE-STAR, Continuum Of Care In Hospitalized Patients With Opioid or Stimulant Use Disorder and Infectious Complications of Drug Use – Substance Use/infectious Disease Integrated Clinic Compared With Treatment as Usual to Prevent Infection Related ReadmissionEPIS, Exploration, Preparation, Implementation, SustainmentIDU, injection drug useIRB, Institutional Review BoardMOUD, medication for opioid use disordersOUD, opioid use disorderPDD, patient-directed dischargePWID, people who inject drugsSIRI, serious injection-related infectionshospitalizationintegrated carelinkage to careopioid use disorderserious injection-related infections (SIRI)Related Concept Videos
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