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A new tunable 3D alveolospheres model from human alveolar epithelial type 2 cells (AEC2) with reduced heterogeneity

Marina Guecamburu1,2,3, Arthur Pavot1,2,3, Amélie Legrix2

  • 1Univ-Bordeaux, Centre de Recherche Cardio-thoracique de Bordeaux, U1045, CIC1401, Pessac, France.

Respiratory Research
|March 18, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
3-D organoidAlveolar epithelial cellsElectron microscopyEmphysemaHydrogel microwells

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The respiratory zone of the human body, which stands in contrast to the conducting zone, comprises the structures that actively participate in the exchange of gases. The initiation of this zone is marked by the terminal bronchioles converging into respiratory bronchioles, the tiniest bronchiole classification. The respiratory bronchioles give way to the alveolar ducts that opens into a congregation of alveoli. Actively involved in gas exchange, alveoli resemble tiny sacs similar to clusters of...

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