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Updated: Mar 19, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Tunable microgel modulars for temporally coordinated combination therapy.

Zhisheng Xiao1, Zhiqiang Wu2, Qiaofeng Li3

  • 1Department of Thoracic Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215123, China; Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|March 18, 2026
PubMed
Summary

This study introduces a modular microgel platform for programmable multi-drug delivery, overcoming challenges in combination therapies. This innovation enables precise temporal coordination of different drug releases for enhanced therapeutic outcomes.

Keywords:
LEGO-inspiredMicrogelModular drug deliveryProgrammable releaseSequential therapy

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Conventional hydrogels face challenges in achieving programmable, multi-drug release for complex combination therapies.
  • Precise temporal coordination of drug release is critical for synergistic therapeutic effects and overcoming drug resistance.

Purpose of the Study:

  • To develop an injectable modular microgel platform for programmable multi-drug delivery.
  • To demonstrate the platform's ability to independently control release profiles of various therapeutic agents.
  • To validate the platform's efficacy in preclinical models for cancer combination therapy.

Main Methods:

  • Fabrication of distinct microsphere modules (e.g., GelMA for hydrophilic, Alginate for hydrophobic drugs).
  • Assembly of composite microgels with tunable matrix concentrations for controlled drug release.
  • In vivo evaluation of injectability, self-healing, retention, and therapeutic efficacy in cancer models.

Main Results:

  • The modular microgels exhibited excellent injectability, rapid self-healing, and prolonged in vivo retention.
  • Tunable release profiles were achieved for diverse agents, from small molecules to proteins.
  • Sequential delivery of carboplatin and RSL3 improved survival by 10 days; co-delivery of doxorubicin and paclitaxel reduced tumor mass 3.53-fold compared to conventional hydrogels.

Conclusions:

  • The modular microgel platform offers a versatile solution for programmable multi-drug delivery, overcoming limitations of monolithic systems.
  • This strategy enables precise temporal control of combination therapies, enhancing therapeutic precision and outcomes.
  • The platform holds significant potential for advancing localized combination cancer therapies.