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Updated: Mar 19, 2026

Mimicking and Manipulating Pancreatic Acinar-to-Ductal Metaplasia in 3-dimensional Cell Culture
Published on: February 11, 2019
Epigenetic dysregulation and microenvironment remodeling in pancreatic cancer
Ningning Niu1, Mo Chen2, Jing Xue1
1State Key Laboratory of Systems Medicine for Cancer, Ren Ji Hospital, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Abstract:
Epigenetic dysregulation including frequent mutations in epigenetic regulators alongside nonmutational reprogramming driven by oncogenic and metabolic stresses represents a hallmark of pancreatic ductal adenocarcinoma (PDAC). Recent advances using low-input epigenomics and single-cell technologies have revealed their role in fostering cellular plasticity, stromal reprogramming, immune evasion, and therapy resistance. This review synthesizes current knowledge of epigenetic mechanisms in PDAC pathogenesis, highlighting their stage- and context-dependent roles in tumor progression, tumor microenvironment crosstalk, and metabolic adaptation. We further highlight emerging therapeutic strategies that target epigenetic vulnerabilities. By integrating cutting-edge epigenomic profiling with functional studies, we outline a roadmap for translating epigenetic discoveries into clinical strategies against this lethal malignancy.
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