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Related Concept Videos

Pericarditis III: Medical Management01:17

Pericarditis III: Medical Management

480
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
480
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

602
Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
602
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

502
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
502
Pericarditis IV: Nursing Management01:25

Pericarditis IV: Nursing Management

527
Pericarditis, an inflammation of the pericardium, necessitates diligent nursing management to ensure effective patient care and recovery. The initial step in managing pericarditis is a comprehensive patient medical assessment.The patient reports chest pain aggravated by breathing, coughing, and swallowing, which worsens when lying supine. The pain often improves when sitting up and leaning forward. Additional symptoms may include fever, malaise, and, in severe cases, signs of heart failure.
527
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

946
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
946
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

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Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
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Hydroxychloroquine for recurrent pericarditis.

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Hydroxychloroquine for recurrent pericarditis: A multicentre observational study.

Lucia Trotta1, Francesco Agozzino1, Silvia Berra1

  • 1Internal Medicine, Fatebenefratelli Hospital, University of Milan, Milan, Italy.

European Journal of Internal Medicine
|March 18, 2026
PubMed
Summary
This summary is machine-generated.

Hydroxychloroquine (HCQ) significantly reduced recurrent pericarditis (RP) episodes and hospitalizations. This treatment also decreased corticosteroid use without notable side effects, improving patient outcomes.

Keywords:
HydroxychloroquineRecurrent pericarditisSteroid-sparing therapy

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Area of Science:

  • Cardiology
  • Rheumatology
  • Pharmacology

Background:

  • Recurrent pericarditis (RP) is a debilitating condition often requiring long-term management.
  • Current treatments for RP can have significant side effects and variable efficacy.

Purpose of the Study:

  • To evaluate the effectiveness and safety of hydroxychloroquine (HCQ) in patients with recurrent pericarditis.
  • To assess the impact of HCQ on pericarditis recurrence rates, hospitalizations, and corticosteroid dependence.

Main Methods:

  • An international longitudinal observational study included 80 patients with idiopathic or post-cardiac injury RP treated with HCQ for at least six months.
  • Data on recurrences, hospitalizations, side effects, and therapies were collected before and after HCQ initiation.
  • Patient and physician-reported outcomes were recorded to assess treatment effectiveness.

Main Results:

  • Among 62 patients treated for at least 12 months, HCQ significantly reduced pericarditis recurrences (median 1 vs. 2, p < 0.001) and hospitalizations (5 vs. 32, p < 0.001).
  • HCQ enabled a significant reduction in corticosteroid use (from 67.5% to 26.3% of patients, p < 0.001) and prednisone dosage.
  • Both patients (80%) and physicians (93.7%) reported positive outcomes regarding HCQ effectiveness, with minimal side effects.

Conclusions:

  • Hydroxychloroquine is an effective treatment for recurrent pericarditis, leading to decreased disease recurrence and hospitalizations.
  • HCQ facilitates a significant reduction in corticosteroid requirements for managing recurrent pericarditis.
  • The treatment demonstrates a favorable safety profile with no relevant adverse effects observed.