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Updated: Mar 19, 2026
COVID-19 Seroprevalence Test for IgG Antibody Levels Among Healthy Donors Across Different Pandemic Phases in Jeddah
Published on: June 24, 2025
[Dynamic Evolution and Clinical Significance of Irregular Erythrocyte Antibodies Distribution in Hospitalized
Yun-Cong Zhang1, Wen-Qing Huang1, Jin-Mu Zhuang1
1Department of Transfusion Medicine, Shenzhen Hospital of Southern Medical University, Shenzhen 518110, Guangdong Province, China.
Objective:
To analyze the distribution trends of irregular erythrocyte antibodies among hospitalized patients in Shenzhen Hospital of Southern Medical University from 2020 to 2024, and to evaluate the impact of Rh-compatible transfusion strategies on antibody profiles, thereby providing evidence for optimizing antigen compatibility protocols.
Methods:
A retrospective study was conducted using data from the Transfusion Laboratory Information Management System (TLIS). Irregular antibody screening and specificity identification were performed using automated microcolumn gel agglutination and manual methods.
Results:
The overall positive rate of irregular antibodies was 0.76% (309/40 646). The proportion of Rh blood group system antibodies significantly decreased from 56.36% (2020) to 21.05% (2024), while MNS system antibodies increased from 7.27% (4/55) to 25.00% (19/76), surpassing Rh antibodies for the first time in 2024. Lewis system antibodies also showed a notable rise (7.77% overall).
Conclusion:
Rh-compatible transfusion effectively reduces Rh-related immunization but shifts antibody burden to MNS and Lewis systems. Regional transfusion protocols should prioritize MNS and Lewis antigen matching, with enhanced screening for Kidd antibodies in high-risk populations.
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