[Analysis of Factors Contributing to Apheresis Platelet Aggregation]

To investigate the influencing factors of apheresis platelet aggregation.

Data from platelet collections by using the Amicus blood cell separator between August 2024 and December 2024 were analyzed. The occurrence of platelet aggregation and its contributing factors were analyzed.

The overall platelet aggregation rate was 16.4%. Aggregation rates in male and female donors were 15.9% and 26.1% , respectively, with no statistically significant difference. Donors with platelet aggregation showed significantly lower HB, HCT, and MCV values but higher Pre-PLT and PCT levels compared to non-aggregated donors. Binary logistic regression analysis revealed that the cause of apheresis platelet aggregation was associated with a history of aggregation and unrelated to other factors. Using aggregation status as the state variable (aggregation=1, non-aggregation=0), the areas under the curve (AUC) for aggregation history, Pre-PLT, and PCT-AUC were 0.784, 0.633, and 0.617, respectively.

Blood donors who have experienced aggregation are more likely to experience aggregation again. In addition, Special attention should be given to donors with elevated Pre-PLT/PCT levels to avoid the occurrence of serious aggregation, and routine practices should mark donors with platelet aggregation history.