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Related Concept Videos

Epistaxis01:30

Epistaxis

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Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
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In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
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Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
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The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
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Related Experiment Video

Updated: Mar 19, 2026

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
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Prophylactic Closure of Mucosal Defect to Prevent Delayed Bleeding After Endoscopic Papillectomy.

Jinpei Dong1, Guigen Teng1, Lu Zhang1

  • 1Department of Gastroenterology, Peking University First Hospital, Beijing, China, pkufh.com.

Canadian Journal of Gastroenterology & Hepatology
|March 18, 2026
PubMed
Summary

Closing resection sites with clips after endoscopic papillectomy (EP) effectively prevents delayed bleeding. This technique is safe, showing no increased risk of pancreatitis or cholangitis in patients undergoing EP for ampullary tumors.

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Area of Science:

  • Gastroenterology
  • Endoscopic Surgery
  • Oncology

Background:

  • Delayed bleeding is a significant complication following endoscopic papillectomy (EP).
  • Preventive strategies are crucial to mitigate post-procedural hemorrhage.

Purpose of the Study:

  • To evaluate the efficacy of prophylactic clip closure in preventing delayed bleeding after EP.
  • To assess the safety of clip closure regarding post-procedure pancreatitis and cholangitis.

Main Methods:

  • Retrospective analysis of 50 patients with ampullary benign tumors undergoing EP.
  • EP performed using snare technique with routine biliary and pancreatic duct stenting.
  • Resection sites were completely closed using hemostatic clips.

Main Results:

  • Delayed bleeding occurred in 4% of patients (mild cases).
  • Post-EP hyperamylasemia (26%) and pancreatitis (14%) were observed, mostly mild.
  • No cases of cholangitis were reported; one intraoperative perforation was managed with clips.

Conclusions:

  • Prophylactic clip closure of resection sites after EP is technically feasible and effective in preventing delayed bleeding.
  • This method does not elevate the risk of post-procedure pancreatitis or cholangitis.