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Deciphering the Association Between Homeostatic Model Assessment of Insulin Resistance and Chronic Diarrhea and the
Yuqun Chen1, Ye Xiao1, Zongtao Chen1
1Health Management Center, First Affiliated Hospital, Army Medical University, Chongqing, China.
Background/Aims:
Metabolic disorders and insulin resistance (IR) may elevate the risk of chronic diarrhea (CrD), yet the association between the homeostatic model assessment of IR (HOMA-IR) and CrD remains unclear. This study aims to examine the HOMA-IR-CrD relationship and investigate the mediating role of lymphocyte-to-monocyte ratio (LMR).
Materials And Methods:
A total of 4984 participants from the National Health and Nutrition Examination Survey database were included. The weighted logistic regression analysis was performed to assess the linkage between HOMA-IR and CrD. Through subgroup analyses, differences in various populations were evaluated. Moreover, mediation analysis was conducted to assess the mediating role of LMR.
Results:
After adjusting for all covariates, HOMA-IR was positively linked with CrD (OR = 1.03, 95% CI: 1.00-1.05). The risk of CrD in the fourth quartile array of HOMA-IR was 1.68 times higher than that in the first quartile array (95% CI: 1.03-2.74). The subgroup analysis revealed a positive correlation between HOMA-IR levels and CrD in females (OR = 1.04, 95% CI: 1.00-1.08), people with a university and above educational background (OR = 1.06, 95% CI: 1.01-1.12), and the current smoking population (OR = 1.07, 95% CI: 1.03-1.12). Furthermore, LMR partially mediated the relationship between HOMA-IR and CrD, with a mediation ratio of 3.76%.
Conclusion:
Elevated HOMA-IR is significantly linked with the risk of CrD, especially in women, people with a university or higher background, and current smokers. The LRM assumes a partial mediating role in that process. The study suggests that interventions targeting IR may contribute to the management and prevention of CrD.
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