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Multimorbidity patterns in elderly sleep disordered breathing patients.

Jeppe Suusgaard1,2, Christine Benn Christiansen3,4, Morten Kjøbek Lambert5,6

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Summary
This summary is machine-generated.

Sleep disordered breathing (SDB) in older adults is linked to higher rates of multiple chronic diseases and increased mortality. Early recognition and integrated care for SDB are crucial in elderly patients with comorbidities.

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Area of Science:

  • Gerontology
  • Sleep Medicine
  • Epidemiology

Background:

  • Multimorbidity, defined as two or more chronic diseases, is prevalent in older adults, contributing to disability and mortality.
  • Sleep disordered breathing (SDB) is an underdiagnosed condition associated with various chronic diseases, but its specific comorbidity patterns in the elderly remain unclear.

Purpose of the Study:

  • To investigate the association between sleep disordered breathing (SDB) and multimorbidity patterns in individuals aged 65 years and older.
  • To assess the impact of SDB on all-cause mortality in the elderly population.

Main Methods:

  • A registry-based case-control study using Danish National Patient Registries (2002-2019).
  • Individuals aged 65+ with SDB were identified and matched 1:4 with controls.
  • Comorbidities were categorized using WHO disease chapters; 22 chronic diseases were assessed within 7 years prior to SDB diagnosis. Logistic and Cox regression models were used.

Main Results:

  • The study included 21,555 SDB patients and 86,212 controls.
  • SDB patients exhibited significantly higher odds of multimorbidity (OR 2.99, p<0.01) across all eight WHO disease groups.
  • Elevated odds were observed for cardiovascular and metabolic diseases (OR 2.52, p<0.01 for both). SDB was linked to increased all-cause mortality (HR 1.09, p<0.01).

Conclusions:

  • Sleep disordered breathing in older adults is significantly associated with multimorbidity and increased all-cause mortality.
  • These findings underscore the importance of recognizing and managing SDB in elderly patients with multiple chronic conditions for improved health outcomes.