Evaluation of Interleukin-1β and Interleukin-6 in the Crevicular Fluid around Healthy Implants and Peri-Implantitis: A Comparative Study
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Updated: Mar 19, 2026

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
Published on: February 16, 2016
Hemant Goyal1, Manoj K Rawat2, Moez I Khakiani3
1Department of Prosthodontics, Crown & Bridge and Oral Implantology, MPCD and RC College, Gwalior, Madhya Pradesh, India.
Background:
The research was carried out to evaluate the levels of interleukin-1β and interleukin-6 in the crevicular fluid surrounding both healthy implants and implants affected by peri-implantitis.
Material And Methods:
A total of 20 dental implants were utilized in a study involving 10 patients, consisting of five males and five females. All clinical assessments were conducted by a qualified periodontist, achieving a reproducibility rate of 95% using a Williams periodontal probe. 1.
Results:
In this study, there were total of 10 subjects out of which five were male and five were female. The mean IL-6 levels around implants with peri-implantitis were 10.23 ± 5.22, IL-6 levels around healthy implants were 8.54 ± 6.21, and IL-6 levels around healthy teeth were 5.11 ± 2.36. The mean IL-1β levels around implants with peri-implantitis were 18.54 ± 9.68, IL-6 levels around healthy implants were 15.23 ± 5.7, and IL-6 levels around healthy teeth were 7.25 ± 2.1.
Conclusion:
In this study's constraints, notable variances can be observed in the concentrations of IL-1β and IL-6 in the crevicular fluid of implants affected by peri-implantitis, unaffected implants, and healthy teeth.

